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fitc标记的转录因子sox10抗体

fitc标记的转录因子sox10抗体价格-博天堂备用

价格: ¥2980

品牌:lmai bio

货号:lm-6449r-fitc

产品详情

文献和实验

商家信息

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供应商:
上海联迈生物工程有限公司
库存:
大量
靶点:
详见说明书
级别:
1
目录编号:
lm-6449r-fitc
克隆性:
多克隆
抗原来源:
rabbit
保质期:
1年
抗体英文名:
anti-sox10/fitc
抗体名:
anti-sox10/fitc
标记物:
fitc标记
宿主:
human, mouse, rat, cow, rabbit,
适应物种:
human, mouse, rat, cow, rabbit,
免疫原:
详见说明书
亚型:
igg
形态:
粉末、液体、冻干粉
应用范围:
if=1:50-200
浓度:
1mg/ml
保存条件:
-20 °c
规格:
100ul
fitc标记的转录因子sox10抗体
英文名称 anti-sox10/fitc
中文名称 fitc标记的转录因子sox10抗体
别    名 dom; mgc15649; sox 10; sox10; sox10_human; sry (sex determining region y) box 10; sry box containing gene 10; sry related hmg box gene 10; transcription factor sox 10; transcription factor sox-10; ws4.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  神经生物学  干细胞  细胞凋亡  表观遗传学  
抗体来源 rabbit
克隆类型 polyclonal
交叉反应 human, mouse, rat, cow, rabbit, 
产品应用 if=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kda
性    状 lyophilized or liquid
浓    度 1mg/ml
免 疫 原 klh conjugated synthetic peptide derived from human sox10
亚    型 igg
纯化方法 affinity purified by protein a
储 存 液 0.01m tbs(ph7.4) with 1% bsa, 0.03% proclin300 and 50% glycerol.
保存条件 store at -20 °c for one year. avoid repeated freeze/thaw cycles. the lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°c. when reconstituted in sterile ph 7.4 0.01m pbs or diluent of antibody the antibody is stable for at least two weeks at 2-4 °c.
产品介绍 background:
transcription factor that seems to function synergistically with the pou domain protein tst-1/oct6/scip. could confer cell specificity to the function of other transcription factors in developing and mature glia. involvement in disease; 
defects in sox10 are the cause of waardenburg syndrome type 2e (ws2e) . ws2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. the frequency of deafness is higher in ws2 than in ws1.
defects in sox10 are a cause of waardenburg syndrome type 4c (ws4c); also known as waardenburg-shah syndrome. ws4c is characterized by the association of waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (hirschsprung disease).
defects in sox10 are a cause of yemenite deaf-blind hypopigmentation syndrome (ydbhs) . ydbhs consists of cutaneous hypopigmented and hyperpigmented spots and patches, microcornea, coloboma and severe hearing loss. another case observed in a girl with similar skin symptoms and hearing loss but without microcornea or coloboma is reported as a mild form of this syndrome.

function:
transcription factor that seems to function synergistically with the pou domain protein tst-1/oct6/scip. could confer cell specificity to the function of other transcription factors in developing and mature glia (by similarity).

subcellular location:
cytoplasm. nucleus

tissue specificity:
expressed in fetal brain and in adult brain, heart, small intestine and colon.

disease:
defects in sox10 are the cause of waardenburg syndrome type 2e (ws2e) [mim:611584]. ws2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. the frequency of deafness is higher in ws2 than in ws1. 
defects in sox10 are a cause of waardenburg syndrome type 4c (ws4c) [mim:613266]; also known as waardenburg-shah syndrome. ws4c is characterized by the association of waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (hirschsprung disease). 
defects in sox10 are a cause of yemenite deaf-blind hypopigmentation syndrome (ydbhs) [mim:601706]. ydbhs consists of cutaneous hypopigmented and hyperpigmented spots and patches, microcornea, coloboma and severe hearing loss. another case observed in a girl with similar skin symptoms and hearing loss but without microcornea or coloboma is reported as a mild form of this syndrome.
defects in sox10 are the cause of peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, waardenburg syndrome, and hirschsprung disease (pcwh) [mim:609136]; also called neurologic variant of waardenburg-shah syndrome. pcwh is a rare, complex and more severe neurocristopathy that includes features of 4 distinct syndromes: peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, waardenburg syndrome, and hirschsprung disease. 

similarity:
contains 1 hmg box dna-binding domain.

database links:

entrez gene: 6663 human

entrez gene: 20665 mouse

entrez gene: 29361 rat

omim: 602229 human

swissprot: p56693 human

swissprot: q04888 mouse

swissprot: o55170 rat

unigene: 376984 human

unigene: 276739 mouse

unigene: 10883 rat



important note:
this product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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地址:上海

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